吕武宏

吕武宏男，1994年03月生，博士研究生，讲师

研究方向

水产动物生理营养代谢调控

教育经历

2021.09-2024.06华中农业大学水产养殖农学博士

2018.09-2021.06华中农业大学渔业发展农业硕士

2014.09-2018.06鲁东大学水产养殖学农学学士

工作经历

2024.12-至今鲁东大学水产学院讲师

2024.07-2024.12浙江海洋大学国家海洋设施养殖工程技术研究中心助理研究员

承担的科研项目

获得2024年国家海洋设施养殖工程技术研究中心开放课题立项，项目编号：NERC202409

论文发表情况

目前，以第一或共同作者发表学术论文二十余篇：

1.LvWH,WuF,SorensenM,TanXY,WeiXL,YuAG,ZhongCC,SongYF,LuoZ.Interactionbetweendietaryzinc(Zn)andmanganese(Mn)ongrowthperformance,intestinalhealthandlipidmetabolisminyellowcatfish.Aquaculture.2024:741809.

2.LvWH,ZhaoT,PantopoulosK,ChenGH,WeiXL,ZhangDG,LuoZ.Manganese-inducedoxidativestresscontributestointestinallipiddepositionviathedeacetylationofPPARγatK339bySIRT1.AntioxidRedoxSignal.2022;37:417-436.

3.LvWH,ChenGH,ZhuoMQ,XuYH,XuYC,TanXY.Functionalanalysisofsteroidogenicfactor1(sf-1)and17α-hydroxylase/lyase(cyp17α)promotersinyellowcatfishPelteobagrusfulvidraco.IntJMolSci.2021;22:195.

4.LvWH,JiangPX,WangWQ,WangXT,WangK,ChangLR,FangY,ChenJ.Electrotransferofsingle-chainLHgeneintoskeletalmuscleinducesearlyovariandevelopmentoforange-spottedgrouper(Epinepheluscoioides).GenCompEndocrinol.2018;259:12-19.

5.ZhaoT,LvWH,HogstrandC,ZhangDG,XuYC,XuYH,LuoZ.Sirt3-Sod2-mROS-mediatedmanganesetriggeredhepaticmitochondrialdysfunctionandlipotoxicityinafreshwaterteleost.EnvironSciTechnol.2022;56:8020-8033.

6.ChenSW,LvWH,WuK,ChenGH,ChenF,SongCC,LuoZ.Dietarynano-ZnOisabsorbedviaendocytosisandZIPpathways,upregulateslipogenesis,andinduceslipotoxicityintheintestineofyellowcatfish.IntJMolSci.2021;22:12047.

7.ChenGH,LvWH,XuYH,WeiXL,XuYC,LuoZ.FunctionalanalysisofMTF-1andMTpromotersandtheirtranscriptionalresponsetozinc(Zn)andcopper(Cu)inyellowcatfishPelteobagrusfulvidraco.Chemosphere.2020;246:125792.

8.ZhuoMQ,LvWH,XuYH,LuoZ.Isolationandcharacterizationofthreesodium-phosphatecotransportergenesandtheirtranscriptionalregulationinthegrasscarpCtenopharyngodonidella.IntJMolSci.2020;21:8228.

9.HeY,ZhaoT,LvWH,TanXY,SongYF,SongCC,ZhongCC,LuoZ.Interactiveeffectsofdietaryzincandwatertemperatureongrowthperformance,Zntransport,heatshockresponseandlipidmetabolismintheliversofjuvenileyellowcatfishPelteobagrusfulvidraco.Aquaculture.2023;562:738795.

10.ChenSW,WuK,LvWH,ChenF,SongCC,LuoZ.Functionalanalysisoftwozinc(Zn)transporters(ZIP3andZIP8)promotersandtheirdistinctresponsetoMTF1andRREB1intheregulationofZnmetabolism.IntJMolSci.2020;21:6135.

11.ChenSW,WuK,LvWH,SongCC,LuoZ.Molecularcharacterizationoftenzinc(Zn)transportergenesandtheirregulationtoZnmetabolisminfreshwaterteleostyellowcatfishPelteobagrusfulvidraco.JTraceElemMedBiol.2020;59:126433.

12.WeiXL,XuYC,TanXY,LvWH,ZhangDG,HeY,LuoZ.Enrofloxacin(ENR)exposureinduceslipotoxicitybypromotingmitochondrialfragmentationviadephosphorylationofDRP1atS627site.Chemosphere.2023;340:139892.

13.WeiX,HogstrandC,ChenG,LvWH,SongY,XuY,LuoZ.ZninduceslipophagyviathedeacetylationofBeclin1andalleviatesCu-inducedlipotoxicityattheirenvironmentallyrelevantconcentrations.EnvironSciTechnol.2021;55:4943-4953.

14.ZhangDG,ZhaoT,XuXJ,LvWH,LuoZ.Dietarymarginalandexcessseleniumincreasedtriglyceridesdeposition,inducedendoplasmicreticulumstressanddifferentiallyinfluencedselenoproteinsexpressionintheanteriorandmiddleintestinesofyellowcatfishPelteobagrusfulvidraco.Antioxidants(Basel).2021;10:535.

15.SongCC,WuLX,ChenGH,LvWH,ChenSW,LuoZ.SixmembersofSLC30A/ZnTsfamilyrelatedwiththecontrolofzinchomeostasis:characterization,mRNAexpressionandtheirresponsestodietaryZnOnanoparticlesinyellowcatfish.Aquaculture.2020;528:735570.

16.WeiXL,ChenGH,XuYC,ZhangDG,LvWH,ZhengH,LuoZ.Zincattenuatessulfamethoxazole-inducedlipotoxicitybyreversingsulfamethoxazole-inducedmitochondrialdysfunctionandlysosomeimpairmentinafreshwaterteleost.Chemosphere.2023;345:140247.

17.LiuX,ZhaoT,WeiX,ZhangD,LvWH,LuoZ.DietaryphosphorusreducedhepaticlipiddepositionbyactivatingAmpkpathwayandBeclin1phosphorylationlevelstoactivatelipophagyintilapiaOreochromisniloticus.FrontNutr.2022;9:841187.

18.ZhongCC,KeJ,SongCC,TanXY,XuYC,LvWH,SongYF,LuoZ.Effectsofdietarycopper(Cu)ongrowthperformance,bodycomposition,mineralcontent,hepatichistologyandCutransportoftheGIFTstrainofNiletilapia(Oreochromisniloticus).Aquaculture.2023;574:739638.

19.WuLX,TanXY,XuYC,ZhengH,WeiXL,LvWH,LuoZ.SIRT1-NRF2-TFEBaxis-mediatedhepaticlipophagyalleviatesthelipiddepositioninducedbyhighglucoseinyellowcatfishPelteobagrusfulvidraco.CompBiochemPhysiolBBiochemMolBiol.2023;269:110894.

20.ChenGH,SongCC,ZhaoT,HogstrandC,WeiXL,LvWH,SongYF,LuoZ.Mitochondria-dependentoxidativestressmediatesZnOnanoparticle(ZnONP)-inducedmitophagyandlipotoxicityinfreshwaterteleostfish.EnvironSciTechnol.2022;56:2407-2420.

21.LeiXJ,ZhangDG,TanXY,ZhaoT,SongYF,SongCC,LvWH,LuoZ.Interactiveinfluencesofdietaryseleniumandoxidizedfishoilongrowth,nutritionalcomposition,muscledevelopment,antioxidantresponsesandselenoproteinexpressioninthemuscleofyellowcatfishPelteobagrusfulvidraco.Aquaculture.2023;576:739865.

22.ZhangDG,KunzWS,LeiXJ,ZitoE,ZhaoT,XuYC,WeiXL,LvWH,LuoZ.Seleniumamelioratedoxidizedfishoil-inducedlipotoxicityviatheinhibitionofmitochondrialoxidativestress,remodelingofUsp4-mediateddeubiquitination,andstabilizationofPparα.AntioxidRedoxSignal.2024;40:433-452.

23.郑华，徐一闯，赵涛，吕武宏，余岸艮，何杨，谭肖英.黄颡鱼STAT3乙酰化位点验证及其与SIRTs去乙酰化酶的关系.水产学报.2022；46：173-182.

24.谌芳，仲崇超，陈姝为，张电光，吕武宏，谭肖英.黄颡鱼溶酶体酸性脂肪酶基因的cDNA序列、启动子及其转录调控分析.水生生物学报.2022；46：98-105.

专利发明

陈军，邹广众，江鹏鑫，李玉茹，金维琦，吕武宏，房燕.鱼类促卵泡激素体细胞基因转移载体及其构建方法与应用，2022-10-25，中国，ZL202210738165.3.

联系方式

电子邮箱：lvwuhong@ldu.edu.cn

手机号：15552263560.