吕武宏

吕武宏 男，1994年03月生，博士研究生，讲师

研究方向

水产动物生理营养代谢调控

教育经历

2021.09-2024.06   华中农业大学    水产养殖      农学博士

2018.09-2021.06   华中农业大学    渔业发展      农业硕士

2014.09-2018.06   鲁东大学       水产养殖学    农学学士

工作经历

2024.12-至今   鲁东大学水产学院                        讲师

2024.07-2024.12   浙江海洋大学国家海洋设施养殖工程技术研究中心     助理研究员

承担的科研项目

获得2024年国家海洋设施养殖工程技术研究中心开放课题立项，项目编号：NERC202409

论文发表情况

目前，以第一或共同作者发表学术论文二十余篇：

1. Lv WH, Wu F, Sorensen M, Tan XY, Wei XL, Yu AG, Zhong CC, Song YF, Luo Z. Interaction between dietary zinc (Zn) and manganese (Mn) on growth performance, intestinal health and lipid metabolism in yellow catfish. Aquaculture. 2024: 741809.

2. Lv WH, Zhao T, Pantopoulos K, Chen GH, Wei XL, Zhang DG, Luo Z. Manganese-induced oxidative stress contributes to intestinal lipid deposition via the deacetylation of PPARγ at K339 by SIRT1. Antioxid Redox Signal. 2022; 37: 417-436.

3. Lv WH, Chen GH, Zhuo MQ, Xu YH, Xu YC, Tan XY. Functional analysis of steroidogenic factor 1 (sf-1) and 17α-hydroxylase/lyase (cyp17α) promoters in yellow catfish Pelteobagrus fulvidraco. Int J Mol Sci. 2021; 22: 195.

4. Lv WH, Jiang PX, Wang WQ, Wang XT, Wang K, Chang LR, Fang Y, Chen J. Electrotransfer of single-chain LH gene into skeletal muscle induces early ovarian development of orange-spotted grouper (Epinephelus coioides). Gen Comp Endocrinol. 2018; 259: 12-19.

5. Zhao T, Lv WH, Hogstrand C, Zhang DG, Xu YC, Xu YH, Luo Z. Sirt3-Sod2-mROS-mediated manganese triggered hepatic mitochondrial dysfunction and lipotoxicity in a freshwater teleost. Environ Sci Technol. 2022; 56: 8020-8033.

6. Chen SW, Lv WH, Wu K, Chen GH, Chen F, Song CC, Luo Z. Dietary nano-ZnO is absorbed via endocytosis and ZIP pathways, upregulates lipogenesis, and induces lipotoxicity in the intestine of yellow catfish. Int J Mol Sci. 2021; 22: 12047.

7. Chen GH, Lv WH, Xu YH, Wei XL, Xu YC, Luo Z. Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco. Chemosphere. 2020; 246: 125792.

8. Zhuo MQ, Lv WH, Xu YH, Luo Z. Isolation and characterization of three sodium-phosphate cotransporter genes and their transcriptional regulation in the grass carp Ctenopharyngodon idella. Int J Mol Sci. 2020; 21: 8228.

9. He Y, Zhao T, Lv WH, Tan XY, Song YF, Song CC, Zhong CC, Luo Z. Interactive effects of dietary zinc and water temperature on growth performance, Zn transport, heat shock response and lipid metabolism in the livers of juvenile yellow catfish Pelteobagrus fulvidraco. Aquaculture. 2023; 562: 738795.

10. Chen SW, Wu K, Lv WH, Chen F, Song CC, Luo Z. Functional analysis of two zinc (Zn) transporters (ZIP3 and ZIP8) promoters and their distinct response to MTF1 and RREB1 in the regulation of Zn metabolism. Int J Mol Sci. 2020; 21: 6135.

11. Chen SW, Wu K, Lv WH, Song CC, Luo Z. Molecular characterization of ten zinc (Zn) transporter genes and their regulation to Zn metabolism in freshwater teleost yellow catfish Pelteobagrus fulvidraco. J Trace Elem Med Biol. 2020; 59: 126433.

12. Wei XL, Xu YC, Tan XY, Lv WH, Zhang DG, He Y, Luo Z. Enrofloxacin (ENR) exposure induces lipotoxicity by promoting mitochondrial fragmentation via dephosphorylation of DRP1 at S627 site. Chemosphere. 2023; 340: 139892.

13. Wei X, Hogstrand C, Chen G, Lv WH, Song Y, Xu Y, Luo Z. Zn induces lipophagy via the deacetylation of Beclin1 and alleviates Cu-induced lipotoxicity at their environmentally relevant concentrations. Environ Sci Technol. 2021; 55: 4943-4953.

14. Zhang DG, Zhao T, Xu XJ, Lv WH, Luo Z. Dietary marginal and excess selenium increased triglycerides deposition, induced endoplasmic reticulum stress and differentially influenced selenoproteins expression in the anterior and middle intestines of yellow catfish Pelteobagrus fulvidraco. Antioxidants (Basel). 2021; 10: 535.

15. Song CC, Wu LX, Chen GH, Lv WH, Chen SW, Luo Z. Six members of SLC30A/ZnTs family related with the control of zinc homeostasis: characterization, mRNA expression and their responses to dietary ZnO nanoparticles in yellow catfish. Aquaculture. 2020; 528: 735570.

16. Wei XL, Chen GH, Xu YC, Zhang DG, Lv WH, Zheng H, Luo Z. Zinc attenuates sulfamethoxazole-induced lipotoxicity by reversing sulfamethoxazole-induced mitochondrial dysfunction and lysosome impairment in a freshwater teleost. Chemosphere. 2023; 345: 140247.

17. Liu X, Zhao T, Wei X, Zhang D, Lv WH, Luo Z. Dietary phosphorus reduced hepatic lipid deposition by activating Ampk pathway and Beclin1 phosphorylation levels to activate lipophagy in tilapia Oreochromis niloticus. Front Nutr. 2022; 9: 841187.

18. Zhong CC, Ke J, Song CC, Tan XY, Xu YC, Lv WH, Song YF, Luo Z. Effects of dietary copper (Cu) on growth performance, body composition, mineral content, hepatic histology and Cu transport of the GIFT strain of Nile tilapia (Oreochromis niloticus). Aquaculture. 2023; 574: 739638.

19. Wu LX, Tan XY, Xu YC, Zheng H, Wei XL, Lv WH, Luo Z. SIRT1-NRF2-TFEB axis-mediated hepatic lipophagy alleviates the lipid deposition induced by high glucose in yellow catfish Pelteobagrus fulvidraco. Comp Biochem Physiol B Biochem Mol Biol. 2023; 269: 110894.

20. Chen GH, Song CC, Zhao T, Hogstrand C, Wei XL, Lv WH, Song YF, Luo Z. Mitochondria-dependent oxidative stress mediates ZnO nanoparticle (ZnO NP)-induced mitophagy and lipotoxicity in freshwater teleost fish. Environ Sci Technol. 2022; 56: 2407-2420.

21. Lei XJ, Zhang DG, Tan XY, Zhao T, Song YF, Song CC, Lv WH, Luo Z. Interactive influences of dietary selenium and oxidized fish oil on growth, nutritional composition, muscle development, antioxidant responses and selenoprotein expression in the muscle of yellow catfish Pelteobagrus fulvidraco. Aquaculture. 2023; 576: 739865.

22. Zhang DG, Kunz WS, Lei XJ, Zito E, Zhao T, Xu YC, Wei XL, Lv WH, Luo Z. Selenium ameliorated oxidized fish oil-induced lipotoxicity via the inhibition of mitochondrial oxidative stress, remodeling of Usp4-mediated deubiquitination, and stabilization of Pparα. Antioxid Redox Signal. 2024; 40: 433-452.

23. 郑华，徐一闯，赵涛，吕武宏，余岸艮，何杨，谭肖英. 黄颡鱼STAT3乙酰化位点验证及其与SIRTs去乙酰化酶的关系. 水产学报. 2022；46：173-182.

24. 谌芳，仲崇超，陈姝为，张电光，吕武宏，谭肖英. 黄颡鱼溶酶体酸性脂肪酶基因的cDNA序列、启动子及其转录调控分析. 水生生物学报. 2022；46：98-105.

专利发明

陈军，邹广众，江鹏鑫，李玉茹，金维琦，吕武宏，房燕. 鱼类促卵泡激素体细胞基因转移载体及其构建方法与应用，2022-10-25，中国，ZL202210738165.3.

联系方式

电子邮箱：lvwuhong@ldu.edu.cn

手机号：17376642019.