鲁东大学水产学院
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王凯

时间:2024年07月18日


  王凯 男,1981年1月生,博士研究生,教授,研究生导师


  研究方向


  鱼类育种、增养殖、环境适应、病害与免疫


  学习经历


  1999.09-2003.07鲁东大学学士生物技术


  2003.09-2006.07云南大学硕士微生物学


  2006.09-2010.06中山大学博士生物化学与分子生物学


  工作经历


  2010.07-2013.05烟台毓璜顶医院技师生殖生物学


  2013.05-2018.01鲁东大学农学院讲师水产养殖


  2018.01-2022.12鲁东大学农学院副教授水产养殖


  2023.01-今鲁东大学农学院教授水产养殖


  科研项目


  (1)国家自然科学基金面上项目:海马免疫响应苯并芘胁迫的权衡策略及性二态产生的分子机制;资助编号:42276118,2023.01-2026.12,主持。


  (2)国家自然科学基金青年项目:致瘤Wnt/β-catenin信号通路与人附睾肿瘤发生率低的相关性研究;资助编号:81302233,2014.01-2016.12,主持。


  (3)山东省现代农业(鱼类)产业技术体系-海水鱼育种岗位专家(SDAIT-12-03);2023-2025,主持。


  (4)山东省重点研发计划(农业良种工程):海马新种质创制及产业化应用;资助编号:2023LZGCQY016,2023.09-2026.08,主持。


  (5)山东省高等学校优秀青年创新团队科技计划项目:水产动物高效繁育创新团队“海马北方高效繁育技术体系构建”;资助编号:2020KJF007,2020.05-2023.04,主持。


  (6)烟台市科技创新发展计划-科技领军人才:海马北方养殖细菌性肠炎生物防控技术研究与示范;资助编号:2020LJRC120,2020.01-2022.12,主持。


  (7)中科院南海所2021年度LMB、LMM、LAMB联合资助开放基金课题:线纹海马免疫响应苯并芘(BaP)亚慢性胁迫的性别差异与分子机制;资助编号:LMB20200103,2021.01-2022.12,主持。


  (8)山东省研究生2021青年导师访学项目,2021.12-2022.12,主持。


  (9)山东省农业地方标准计划项目:线纹海马人工繁殖技术操作规程;2019.04-2020.04,主持。


  (10)山东省高校科技计划项目:线纹海马对苯并芘亚慢性胁迫免疫响应的分子机制;资助编号:J18KA146,2018.01-2021.01,主持。


  (11)横向课题:海马室内人工繁育技术培训与咨询服务;2021.11-2022.11,主持。


  (12)横向课题:海马北方高效繁育技术体系构建及示范;2019.01-2021.12,主持。


  (13)横向课题:海马北方高效养殖及细菌病害检测、防控技术;2017.01-2020.01,主持。


  (14)烟台市科技发展计划项目:美国线纹海马北方高效养殖关键技术研究;资助编号:2016ZH062,2016.01-2018.12,主持。


  (15)校级教改课题:学业导师指导下的本科生“三位驱动”生产实习模式的探索与实践;资助编号:2019J58,2019.03-2021.03,主持。


  (16)校级教学成果培育项目:学业导师指导下的本科生“三位驱动”生产实习模式的探索与实践;资助编号:2020C03,2020.07月2022.07,主持。


  (17)鲁东大学科学启动基金:海马催产剂研发及应用初探,资助编号:ZR2013CM026,2013.10-2016.10,主持。


  发表论文


  (1)Wang Kai*#,XueYuanyuan#,Liu Yali*,Su Xiaolei,Wei Lei,LvChunhui,Zhang Xu,Zhang Lele,JiaLongwu,ZhengShiyi,Ma Yicong,YanHansheng,JiangGuangjun,Song Hongce,Wang Fang,LinQiang,HouYuping.The detoxification ability of sex-role reversed seahorses determines the sexual dimorphism in immune responses to benzo[a]pyrene exposure.Science of the Total Environment,933,173088,2024.(SCI一区Top,IF:9.8)


  (2)Zhang Lele#,Wang Fang#,Jia Longwu,Yan Hansheng,Gao Longkun,Tian Yanan,Su Xiaolei,Zhang Xu,Lv Chunhui,Ma Zhenhao,Xue Yuanyuan,Lin Qiang and Wang Kai*.Edwardsiella piscicida infection reshapes the intestinal microbiome and metabolome of big-belly seahorses:mechanistic insights of synergistic actions of virulence factors.Frontiers in Immunology,14,1135588,2023.(SCI二区Top,IF:8.786)


  (3)Tian Yanan#,Wang Fang#,Su Xiaolei,Zhang Lele,Ma Zhenhao,Gao Longkun,Yan Hansheng,Xue Yuanyuan,Lv Chunhui,Zhang Xu,Li Mingzhu,Hou Yuping,Wang Kai*.Supplementation with Enterococcus faecium enhances growth performance,intestinal health and immunity of big-belly seahorses(Hippocampus abdominalis)during diet conversion.Aquaculture Reports,28,101466,2023.(SCI二区,IF:3.385)


  (4)Wang Kai*#,Wang Xin#,Zou Qiang,Jiang Han,Zhang RongRong,Tian YaNan,Zhang LeLe,Lin Qiang*.Genome-wide evolutionary characterization of MAPKs family and their expression profiles in response to bacterial infection in lined seahorses Hippocampus erectus.Journal of Oceanology and Limnology,39(6):2309-2321,2021.DOI:10.1007/s00343-020-0332-y(SCI二区,IF:0.621)


  (5)Li CY#,Olave M#,Hou YL#,Qin G#,Schneider R#,Gao ZX#,Tu XL,Wang X,Qi FR,Nater A,Kautt A,Wan SM,Zhang YH,Liu YL,Zhang HX,Zhang B,Zhang H,Qu M,Liu SS,Chen ZY,Zhong J,Zhang H,Meng LF,Wang K,Yin JP,Huang LM,Venkatesh B*,Meyer A*,Lu XM*,Lin Q*.Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution.Nature Communications,12:1094,2021.(SCI一区Top,IF:12.121)


  (6)Wang Xiaomeng#,Wang Fang#,Chen GuoZhong,Yang BoYa,Chen Jun,Fang Yan,Wang Kai*,Hou Yuping*.Edwardsiella tarda induces enteritis in farmed seahorses(Hippocampus erectus):An experimental model and its evaluation.Fish&Shellfish Immunology,98:391-400,2020.(SCI一区Top,IF:3.298)


  (7)Chen Jun,Jiang Han,Wang Xiaomeng,Wang Lei,Ji DaoDe,Liu HuiLian,Wang Kai*.Novel co-infection by ciliates and barentsia outbreak in large-scale cultured lined seahorse(Hippocampus erectus)in the northern China.Aquaculture Research,51(2):867-872,2020.(SCI三区,IF:1.502)


  (8)Jiang Han,Wang Kai*,Fang Yan,Chen Jun,Li YanMin,Xia GuangBo,Zhang YingFeng,Liu Yu,Ren ChuanBo,Lin Qiang*.Sex-biased regulation of respiratory burst,phagocytic activity and plasma immune factors in lined seahorse(Hippocampus erectus)after subchronic benzo[a]pyrene exposure.Fish&Shellfish Immunology,86:1162-1168,2019.(SCI一区Top,IF:3.298)


  (9)Wang WenQiang,Chen Jun*,Fang Yan,Wang Bin,Zou Qiang,Wang Lei,Zhang WenWen,Huang XueYing,Lv HaoYue,Zhang ChenXiao,Wang Kai*.Identification of gnrh2 and gnrh3 and their expression during brood pouch growth and short-term benzo(a)pyrene exposure in lined seahorse(Hippocampus erectus).Comparative Biochemistry and Physiology,Part C-Toxicology&Pharmacology 225,2019.(SCI三区,IF:2.697)


  (10)Wang Kai*,Li KunMing,Shao JunFeng,Hu WenJing,Li Min,Yang Wen,Tian JiTeng,Lin Qiang*.Yeast and Corn Flour Supplement Enhances Large-scale Culture Efficiency of Marine Copepod Tisbe Furcata,a Potential Live Food for Fish Larvae.The Israeli Journal of Aquaculture-Bamidgeh,69,2017.(SCI四区,IF:0.348)


  (11)Lin Qiang*,Fan ShaoHua,Zhang YanHong,Xu Meng,Zhang HuiXian,Yang YuLan,Lee Alison P.,Woltering Joost M.,Ravi Vydianathan,Gunter Helen M.,Luo Wei,Gao ZeXia,Lim Zhi Wei,Qin Geng,Schneider Ralf F.,Wang Xin,Xiong PeiWen,Li Gang,Wang Kai,Min JiuMeng,Zhang Chi,Qiu Ying,Bai Jie,He WeiMing,Bian Chao,Zhang XinHui,Shan Dai,Qu HongYue,Sun Ying,Gao Qiang,Huang LiangMin,Shi Qiong,Meyer Axel&Venkatesh Byrappa.The seahorse genome and the evolution of its specialized morphology.Nature,540:395-399,2016.(封面文章)(SCI一区Top,IF:43.76)


  (12)Wang Kai,Zhang YanHong,Li Feng,Lin Qiang*.Comparison of intestinal microbiota in intestinal tracts of the wild and cultured seahorses,Hippocampus trimaculatus(Leach).Journal of the World Aquaculture Society,47(1):792-797,2016.(SCI四区,IF:1.386)


  (13)Li Feng#,Wang Kai#,Luo Wei,Huang LiangMin,Lin Qiang*.Comparison of the intestinal bacterial flora in healthy and intestinal-diseased seahorses Hippocampus trimaculatus,H.erectus,and H.spinosissimus.Journal of the World Aquaculture Society,46(3):263-272,2015.(SCI四区,IF:1.386)


  (14)Wang Kai*,Li Ning,Yeung ChingHei,Cooper Trevor G,Liu XueXia,Liu Juan,Wang WenTing,Li Yan,Shi Hui,Liu FuJun.Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mouse and human epididymis.Asian Journal of Andrology,17:1-6,2015.(SCI三区Top,IF:2.862)


  (15)Wang Kai,Li Ning,Yeung Ching-Hei,Li JianYuan,Wang HaiYan,Cooper Trevor Graham*.Oncogenic Wnt/β-catenin signalling pathways in the cancer-resistant epididymis has implications for cancer research.Molecular Human Reproduction,19(2):57-71,2013.(SCI二区,IF:3.943)


  (16)Wang Kai,Diao LiangHui,Gong Yu,Liu Xin,Li YingQiu*.NEMO differentially regulates TCR and TNF-alpha induced NF-kappaB pathways and has an inhibitory role in TCR-induced NF-kappaB activation.Cellular Signalling,24:1556-1564,2012.(SCI二区,IF:4.191)


  (17)Wang Kai,Zhao ZhiWei*.Occurrence of Arbuscular Mycorrhizas and Dark Septate Endophytes in Hydrophytes from Lakes and Streams in Southwest China.International Review of Hydrobiology,91(1):29-37,2006.(SCI四区,IF:2.533)


  (18)张乐乐,邹强,田雅楠,吕春晖,郑诗怡,姜广峻,高龙坤,侯玉平,王凯*.线纹海马肠道菌群结构与功能对迟钝爱德华氏菌(Edwardsiella tarda)感染的响应特征研究.热带海洋学报,2022,41(2):177-188.


  (19)王凯*,李坤明,胡文靖,邵君凤,洋雯,李敏,附着基对分叉小猛水蚤(Tisbe furcata)种群密度及水体化学要素的影响.生态科学,35(5):1-7,2016.


  (20)王凯*,李坤明,洋雯,李敏,吕德亮,林强,水体化学要素对分叉小猛水蚤(Tisbe furcata)和小拟哲水蚤(Paracalanus parvus)室内养殖种群密度的影响.生态科学,34(6):105-110,2015.


  (21)Lele Zhang#,Fang Wang#,Chunhui Lv,Lanliang Yu,Xiaojing Ci,Ning Zhang,Longwu Jia,Yuanyuan Xue,Xu Zhang,Xiaolei Su*,Kai Wang.Identification of CTNNB1 in the lined seahorse(Hippocampus erectus)and its function in innate immunity and cell proliferation.Journal of theWorld Aquaculture Society,e13061,2024.https://doi.org/10.1111/jwas.13061.(SCI三区,IF:2.8)


  (22)Yeung Ching-Hei,Wang Kai,Cooper Trevor Graham*.Why are epididymal tumours so rare?Asian Journal of Andrology,14(3):465-475,2012.(SCI三区Top,IF:2.862)


  (23)王凯,赵之伟*.云南部分地区湿地植物的丛枝菌根初报.云南植物研究,28(4):349-351,2006.


  (24)Yeung Ching-Hei,Wang Kai,Cooper Trevor Graham*.Why are epididymal tumours so rare?Asian Journal of Andrology,14(3):465-475,2012.(SCI三区Top,IF:2.862)


  (25)Shujuan Zhang,Xuyang Chen,Mingli Shao,Jingjing Zhang,Kai Wang,Gang Lin,Mingzhu Li*.Hepatopancreatic transcriptome profiles reveal the effects of toxic dietary concentrations of selenium on the immunity and growth of juvenile abalone Haliotis discus hannai,Aquaculture Reports,28,101449,2023.(SCI二区,IF:3.385)


  (26)Dong ShiHang,Yang YanYan,Cheng Bo,Ren ChuanBo,Zhang HuaWei,Xu Hua,Zhu Na,Wang WanSheng,Dang YongJian,Li MingZhu,Chen Jun,Wang Kai,Zhang LiBin,Fang Yan*.Responses of antioxidant defenses in the clam Mactra veneriformis to 2,2’,4,4‑tetrabromodiphenyl ether exposure.Comparative Biochemistry and Physiology,Part C-Toxicology&Pharmacology 217:98-105,2019.(SCI三区,IF:2.697)


  (27)Lv WuHong,Jiang PengXin,Wang WenQiang,Wang XiaoTong,Wang Kai,Chang LinRui,Fang Yan,Chen Jun*.Electrotransfer of single-chain LH gene into skeletal muscle induces early ovarian development of orange-spotted grouper(Epinephelus coioides).General and Comparative Endocrinology,259:12–19,2018.(SCI四区,IF:2.445)


  (28)Li Ning,Li ShuHong,Wang YanWei,Wang JiaHui,Wang Kai,Liu Xin,Li Yan and Liu Juan*.Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated Wnt/β-catenin signaling pathway.Cell Biology International,41(8):898-907,2017.(SCI四区,IF:2.127)


  所获奖励


  (1)2016、2017、2019-2023年度鲁东大学先进工作者;2015、2016、2017、2019、2020、2022年度鲁东大学优秀党员;2020、2022年师德考核优秀


  (2)2022年度海洋科学技术奖一等奖


  海洋典型卵胎生鱼类资源保护与健康繁殖技术推广及应用


  主要完成单位:中国科学院南海海洋研究所、浙江海洋大学、鲁东大学、天津农学院、中国水产科学研究院东海水产研究所、中国科学院海洋研究所、山东省渔业发展和资源养护总站


  主要完成人:林强、高天翔、秦耿、王凯、孙金辉、王信、林听听、张辉、殷建平、涂忠、张艳红、张辉贤、肖旺红、王晓艳、黄良民


  (3)2022年度“中国好技术”


  海马室内工厂化健康养殖技术


  主要完成单位:鲁东大学


  主要完成人:王凯、侯玉平、林强、李坤明等


  批准部门:中国生产力促进中心协会


  (4)2017年山东省优秀学士学位论文,指导教师;


  (5)指导学生省级以上创新、创业获奖:


  2020年第十三届全国大学生创新创业年会入选项目;


  2019年第十六届“挑战杯”全国大学生课外学术科技作品竞赛三等奖;第十六届“挑战杯”山东省大学生课外学术科技作品竞赛一等奖、第六届山东省大学生科技创新大赛二等奖(两项);


  2018年“创青春”海尔山东省大学生创业大赛银奖;“建行杯”第四届山东省“互联网+”大学生创新创业大赛铜奖;


  2017年第三届山东省“互联网+”大学生创新创业大赛铜奖;第十五届挑战杯山东省大学生课外学术科技作品竞赛三等奖;


  2016年“创青春”山东省大学生创业大赛金奖;


  (6)2016年鲁东大学教学观摩活动院级优秀;


  (7)2015年鲁东大学优秀学士论文,指导教师;


  发明专利


  (1)王凯,李坤明,洋雯,李敏,吕德亮,林强.一种桡足类的室内大池高密度养殖方法,2015,ZL 201510350289.4;


  (2)王凯,李坤明,张志华,胡文靖,邵君凤,王树茂,邹柏强,李敏,洋雯,林强.一种海马养殖池,2015,ZL 201510350492.1;


  (3)王凯,李坤明,李敏,洋雯,吕德亮,林强.一种桡足类室内大规模、高密度养殖饵料,2015,ZL 201510350185.3;


  (4)王凯,李坤明,邵君凤,胡文靖,林强.一种卤虫的室内低成本、高密度、可持续养殖方法,2016,ZL 201610205991.6;


  (5)王凯,林强,陈军,房燕,姜韩,王晓蒙,夏广波,张英凤,王思聪,杨博雅.一种根据生产需求调控的亲海马交配繁育方法,2018,ZL 201811273236.7;


  (6)王凯,田雅楠,侯玉平,张乐乐,薛圆圆,吕春晖,张旭,高龙坤,马振豪,姜广峻,郑诗怡,贾龙武,闫瀚升,俞兰良,秦耿,刘雅莉,林强.一株屎肠球菌LD-NXY01及其在海马养殖中的应用,2022,ZL 202210536805.2;


  学术交流


  参加2021第四届世界海龙科生物学大会(4th SyngBio Symposium),作为六个分会之一Aquaculture&Environment Session的主席,主持并做题为“Research model and its evaluation of seahorse bacterial enteritis”的会议报告


  参加2020滨州第二次海马产业发展研讨会做题为“海马北方高效繁育技术”的大会报告


  参加2019青岛中国水产学会鱼病专业委员会2019学术讨论会


  参加2015韩国济州岛举办的世界水产大会并在海马分会上做题为“海马肠道微生物菌群”的口头报告


  参加2014澳大利亚阿德莱德举办的世界水产大会


  参加2014上海举办的第六届国际副睾大会并做海报展示


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